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Catechin-7-O-xyloside

Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.

Catalog No. TN5440Cas No. 42830-48-8

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Catechin-7-O-xyloside

Catalog No. TN5440Cas No. 42830-48-8

Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.

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5 mg	$1,809	Backorder

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Product Introduction

Bioactivity

Description	Catechin-7-O-xyloside(C7Ox) has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.
In vitro	C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation[1].
In vivo	Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA[1].
Alias	Catechin 7-O-β-D-xylopyranoside

Chemical Properties

Molecular Weight	422.38
Formula	C₂₀H₂₂O₁₀
Cas No.	42830-48-8

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Keywords

Catechin 7-O-b-D-xylopyranosideCatechin 7-O-beta-D-xylopyranosideCatechin-7-O-xyloside